The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

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The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

RNA-binding proteins of the L7Ae family are at the heart of many essential ribonucleoproteins (RNPs), including box C/D and H/ACA small nucleolar RNPs, U4 small nuclear RNP, telomerase, and messenger RNPs coding for selenoproteins. In this study, we show that Nufip and its yeast homologue Rsa1 are key components of the machinery that assembles these RNPs. We observed that Rsa1 and Nufip bind se...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2008

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200708110